How effective is antibody testing for diagnosing COVID-19? What can a population-based study that tested 86% of the population in an Italian town tell us about infection rates?
The accuracy of antibody tests for COVID-19 are highly variable. The results from a study that tested an entire town in Italy during the peak of the epidemic suggest an infectious period between 3.6 days to 6.5 days, with infectiousness peaking on the day of symptom onset.
How should diabetes be managed in patients who choose to fast during Ramadan?
These expert-derived guidelines are updated from <a href="https://www.essentialevidenceplus.com/content/poem/71256">earlier recommendations</a> for managing diabetes in Muslim patients who desire to fast during Ramadan. The updated guidelines focus on newer hypoglycemic agents and management during the COVID-19 pandemic. See the paper for more details.
Does use of angiotensin converting enzyme inhibitors (ACEIs) or angiotensin receptor blockers (ARBs) increase the likelihood or severity of COVID-19 infection?
This large and well-conducted Italian case-control study found no association between the use of angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin receptor blockers (ARBs) and either infection or severe illness with COVID-19. <a href="https://www.nejm.org/doi/10.1056/NEJMoa2008975">Another study</a> in the same issue of the journal used data from New York City and came to the same conclusions.
Can patient-collected swabs accurately detect the presence of SARS-CoV-2? What symptoms and laboratory findings are common in patients with COVID-19?
Self-collected swabs are accurate in detecting SARS-CoV-2 in ambulatory settings. Fever, cough, elevated C-reactive protein levels, and ground glass opacities are common in patients with COVID-19 in China.
Can corticosteroids reduce mortality in hospitalized patients with COVID-19 who require oxygen or ventilation? Can postexposure prophylaxis with hydroxychloroquine improve outcomes?
Corticosteroids reduce mortality in hospitalized patients with COVID-19 who require oxygen or ventilatory support. In healthy people, postexposure prophylaxis with hydroxychloroquine is not effective.
Is remdesivir safe and effective for the treatment of COVID-19?
Remdesivir provides a clinically and statistically significant reduction in the duration of symptoms of COVID-19. Questions remain regarding its effects on mortality and on patients who have advanced disease that requires mechanical ventilation or extracorporeal membrane oxygenation (ECMO).